Fig. 5

Mapping of RNAseq data (PEG vs. NC) to top KEGG pathways from clusters 1 and 4. a Allograft rejection pathway (2nd most highly enriched for downregulated transcripts in the PEG vs. NC comparison) showing key molecules and processes involved in allograft rejection (ordered left to right in the diagram). Upregulated transcripts (pink tiles), downregulated transcripts (blue tiles), and transcripts that are part of the pathway, but not included in our list of DEGs (white tiles) are shown. Solid arrows represent protein interactions, while dashed arrows pointing to or from T cells represent T cell differentiation into effector phenotypes. Dotted arrows point to a subsequent event. b ECM-receptor interaction pathway (most highly enriched for upregulated transcripts in the PEG vs. NC comparison) showing binding interactions between extracellular matrix proteins and either integrins, proteoglycans, glycoproteins, or immunoglobulin superfamily (Ig-SF) members. These diagrams have been stylistically modified from the original KEGG diagrams for display purposes