Fig. 6
Among the Iba1-positive cells, reduced Ta (upper plot) 24 h after LPS administration resulted in an increased number of MMP-9 positive cells (a), number of TUNEL positive cells (b), and number of invading polymorphonuclear cells (PMN, c) appearing mainly in the brains obtained from PI3Kγ-deficient mice. Values are presented as boxplots illustrating medians within boxes from first quartile to the third quartile and whiskers ranging from the 10th to the 90th percentiles (lower panel: neutral Ta, upper panel: reduced Ta, n = 4 per each group and experimental state. * § † p < 0.05, asterisk indicates significant differences versus baseline of the same genotype and experimental state, section sign indicates significant differences versus wild type mice kept under same Ta, dagger sign indicates significant differences versus mice kept under neutral Ta at the same experimental state, two-way ANOVA, followed by Holm–Sidak test for post hoc multiple comparisons, each)