Fig. 11

TGM inhibition reduces the cerebellar in Smox/Sat1-dKO mice. a, b Microscopic examination of cerebellar histopathology and demyelination in comparable sections obtained from Wt, Wt + Cys, Smox/Sat1-dKO, and Smox/Sat1-dKO + Cys mice at 16 weeks of age. Black arrows in A point out the areas of Purkinje cell damage and white matter demyelination. Black arrows in B point to the areas of white matter demyelination. c FJC staining of Wt, Wt + Cys, Smox/Sat1-dKO, and Smox/Sat1-dKO + Cys mice. White arrows point to degenerating Purkinje cells. d Western blot analysis of proteins associated with cerebellar injury in Wt, Wt + Cys, Smox/Sat1-dKO, and Smox/Sat1-dKO + Cys mice (results are representative of 3 independent experiments). Western blots contained 50 μg/lane of protein