Fig. 3
Development of ataxia in Smox/Sat1-dKO mice is due to selective cerebellar damage. a Comparison of the MRI images of Wt (n = 6) and Smox/Sat1-dKO mice (n = 4) revealed the latter to have severe cerebellar edema (hyperintense, white colored, region in the cerebellum) without any changes in the cerebrum. b Comparison of the volumetric MRI results of Wt (n = 6) and Smox/Sat1-dKO mice (n = 4) revealed that the latter have significantly reduced WM volume (p = 5.90 × 10−5) and elevated CSFV (p = 7.35 × 10−4). c Metabolic MRI also revealed significantly decreased of glutamate (p = 0.0036), N-acetylaspartate (p = 0.0096), and elevated inositol (p = 0.013) to creatine ratios. (*) denotes p < 0.05 and (**) denotes p < 0.01