Skip to main content
Fig. 4 | Journal of Neuroinflammation

Fig. 4

From: Ablation of polyamine catabolic enzymes provokes Purkinje cell damage, neuroinflammation, and severe ataxia

Fig. 4

Ataxia in Smox/Sat1-dKO mice is associated with early Purkinje cell damage followed by white matter injury and leptomeningeal leukocyte infiltration. a Representative H&E stained sections of the cerebellum revealed the presence of Purkinje layer vacuolization (black arrows) and severe demyelination (black box) in the cerebellar white matter of the Smox/Sat1-dKO mice (large black arrows, top far right panel). b Examination of comparable cerebellar regions indicates apparent Purkinje cell loss (black arrows) and leptomeningeal leukocyte infiltration (blue arrow) in ataxic mice

Back to article page