Role of sex and high-fat diet in metabolic and hypothalamic disturbances in the 3xTg-AD mouse model of Alzheimer’s disease

Table 1 Sex- and genotype-specific correlations between metabolic outcomes and hypothalamic abnormalities

	WT MALES		AD MALES		WT FEMALES		AD FEMALES
	R	p	R	p	R	p	R	p
Weight gain vs. IL-6 (hyp)	− 0.049	0.863	− 0.587	0.017*	− 0.201	0.473	− 0.395	0.230
Weight gain vs. IL-1β (hyp)	0.201	0.491	0.280	0.312	− 0.401	0.155	0.806	0.0012**
Weight gain vs. GFAP (hyp)	− 0.231	0.408	− 0.164	0.544	0.217	0.456	0.891	< 0.0001****
Leptin (plasma) vs. GFAP (hyp)	− 0.239	0.454	− 0.333	0.267	0.182	0.593	0.756	0.030*
IL-1β (hyp) vs. GFAP (hyp)	0.004	0.988	0.043	0.878	0.432	0.140	0.935	< 0.0001****
Weight gain vs. Iba1 (PVN)	0.031	0.933	0.704	0.051	− 0.069	0.870	0.775	0.009**
Weight gain vs. GFAP (ARC)	− 0.022	0.956	− 0.005	0.992	0.490	0.151	0.780	0.008**
Weight gain vs. GFAP (DMH)	0.759	0.018*	0.755	0.030*	0.854	0.002**	0.932	< 0.0001****
Weight gain vs. GFAP (VMH)	0.237	0.510	0.389	0.341	0.501	0.140	0.834	0.003**
Weight gain vs. GFAP (PVN)	− 0.169	0.663	0.357	0.432	− 0.074	0.839	0.857	0.003**

Correlations were run for each sex/genotype (WT males, AD males, WT females, AD females), combining mice across control and high fat diets, to explore relationships between metabolic outcomes and hypothalamic abnormalities. *p < 0.05, **p < 0.01, ***p < 0.001, ****p < 0.0001

ISSN: 1742-2094