Fig. 2

Decreased expression of miR-29 subtypes in human MG thymuses. a miR-29 subtypes expression was assessed using data from a thymic miRnome study [10]. Each point corresponds to the mean of raw intensity values for 6 non-MG adult control thymuses and 12 MG thymuses. p value was assessed by the Wilcoxon test. b–h miR-29 subtypes expression was assessed by RT-PCR in 6 non-MG adult control thymuses and 12 MG thymuses. b Each point corresponds to the mean values for the controls and MG thymuses. p values were assessed by the Wilcoxon test. c, e, g Detailed expression of miR-29a-3p, miR-29b-3p, and miR-29c-5p in control and MG thymuses with a low (orange dots) and high (red dots) degree of thymic hyperplasia. Data were normalized to the 28S. p values were assessed by the Mann-Whitney test. d ,f ,h Analyses of the sensitivity and specificity with ROC curves for miR-29a-3p, miR-29b-3p, and miR-29c-5p* in control and MG thymuses