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Fig. 5 | Journal of Neuroinflammation

Fig. 5

From: PET imaging of P2X7R in the experimental autoimmune encephalomyelitis model of multiple sclerosis using [11C]SMW139

Fig. 5

Time activity curves (TAC) of [11C]SMW139 uptake in the spinal cord (a), cerebellum (b), and brain stem (c) (%ID/mL) of five rats that developed severe EAE and of which two rats developed a relapse and three did not develop any relapse. TAC of all the rats at the peak of the disease (11–12 days post immunization (dpi)) (white circle), the two rats that developed a relapse during the relapse phase (24–26 dpi) (pink square), the three rats that did not develop a relapse but imaged at the same time as the relapse phase (24–26 dpi) (white square), and all the animals at the recovery phase (47–49 dpi) (blue circle). Quantification of PET imaging in the spinal cord, cerebellum, and brain stem of a single frame static reconstruction between 5 and 45 min post [11C]SMW139 injection (d). Sagittal PET images extracted from the static reconstruction of the 5–45 min frame and showing [11C]SMW139 uptake in the brain and spinal cord (arrows) of relapsing EAE rat (peak of the disease (e), relapse (f), recovery (g)) and non-relapsing rat (peak of the disease (h), no-relapse (i), recovery (j)). S.C. spinal cord, CB cerebellum, B.S. brain stem. Data are expressed as percent injected dose per milliliter (%ID/mL)

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