Fig. 6

Specific blocking of [¹¹C]SMW139 uptake in the brain of EAE animals at the peak of the disease and in the recovery phase. Time activity curves showing the ratio to reference region of [¹¹C]SMW139 uptake in the spinal cord (a, b), cerebellum (c, d), and brain stem (e, f) before and after blocking with JNJ-47965567 (30 mg/kg) at the peak of the disease and in the recovery phase. Ratio to reference region of [¹¹C]SMW139 uptake in spinal cord (g), cerebellum (h), and brain stem (i) of a single-frame static reconstruction between 5 and 45 min at the peak of the disease and in the recovery phase. (*, p < 0.05; **, p < 0.001)