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Fig. 8 | Journal of Neuroinflammation

Fig. 8

From: PET imaging of P2X7R in the experimental autoimmune encephalomyelitis model of multiple sclerosis using [11C]SMW139

Fig. 8

Autoradiography with [3H]SMW139 and immunofluorescence staining on spinal cord tissue from EAE animals at the peak of the disease. Autoradiograph showing the binding of [3H]SMW139 on spinal cord tissue from EAE animals at the peak of the disease (a) and blocking with JNJ-54173717 (b). Graph showing the autoradiography quantification of the [3H]SMW139 total binding and block (n = 3 different animals, n = 26 different sections) (c). Images are showing P2X7R (red) and CD11b (green) double staining (d) and P2X7R (red) and CD68 (green) double staining (e)

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Journal of Neuroinflammation

ISSN: 1742-2094