Fig. 8
Autoradiography with [3H]SMW139 and immunofluorescence staining on spinal cord tissue from EAE animals at the peak of the disease. Autoradiograph showing the binding of [3H]SMW139 on spinal cord tissue from EAE animals at the peak of the disease (a) and blocking with JNJ-54173717 (b). Graph showing the autoradiography quantification of the [3H]SMW139 total binding and block (n = 3 different animals, n = 26 different sections) (c). Images are showing P2X7R (red) and CD11b (green) double staining (d) and P2X7R (red) and CD68 (green) double staining (e)