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Fig. 3 | Journal of Neuroinflammation

Fig. 3

From: Evaluation of neurofilament light chain in the cerebrospinal fluid and blood as a biomarker for neuronal damage in experimental pneumococcal meningitis

Fig. 3

Inflammatory CSF cytokines and MMP-9/MMP-2 levels during ePM. At 18 hpi before treatment with ceftriaxone, infected animals displayed significant higher TNF-α (p = 0.01) (n = 11) (a), IL-6 (p < 0.001) (n = 12) (b), IL-1β (p < 0.001) (n = 12) (c), and MMP-9/MMP-2 (p < 0.001) (n = 12) (d) levels compared to mock-infected animals (n = 5 for all cytokines and MMP9-/MMP-2). At 42 hpi, concentrations of TNF-α (a) and IL-6 (b) were similar in mock-infected (n = 8; n = 11) and infected animals (n = 6; n = 18) whereas IL-1β (p = 0.02) (n = 17) (c) and MMP-9/MMP-2 (p < 0.0001) (n = 17) (d) were still higher in infected compared to mock-infected ones (n = 12; n = 7)

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