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Table 1 The effects of FTS•B on cytokines levels in the serum of APP/PS1 mice

From: Forsythoside B attenuates memory impairment and neuroinflammation via inhibition on NF-κB signaling in Alzheimer’s disease

 

WT

APP/PS1

 

FTS•B (mg/kg)

10

40

TLR3 (ng/mL)

29.6 ± 1.6

21.7 ± 1.9##

27.3 ± 1.7*

29.8 ± 1.2**

p-IRF3/IRF3

1.2 ± 0.1

0.8 ± 0.0##

0.9 ± 0.1*

0.9 ± 0.0*

IFN-β (pg/mL)

95.4 ± 7.0

51.5 ± 7.2###

89.8 ± 15.4*

90.7 ± 6.3***

JIP3 (ng/L)

233.9 ± 41.7

379 ± 35.9##

274.7 ± 57

219.9 ± 40.9**

p-JNK/JNK

5.3 ± 0.6

8.4 ± 1.0##

5.3 ± 0.8*

5.4 ± 0.6*

p-APP/APP

0.2 ± 0.0

0.4 ± 0.1##

0.2 ± 0.1**

0.3 ± 0.1**

Aβ (mg/L)

2.5 ± 0.2

3.0 ± 0.1#

2.4 ± 0.2**

2.3 ± 0.2**

TNF-α (ng/L)

132.6 ± 13.2

189.7 ± 22.6#

101.5 ± 25.3**

103 ± 17.7**

IL-1β (ng/L)

91 ± 6.1

124.9 ± 8.9#

95.9 ± 4.9**

87.8 ± 7.6**

IL-6 (pg/mL)

193.1 ± 8.9

223.7 ± 7.8#

190.2 ± 7.5**

177.9 ± 11.9**

IL-8 (pg/mL)

367.3 ± 23.2

471.8 ± 22.9##

364.1 ± 37.8*

310.3 ± 22.9***

IL-12 (ng/L)

58.6 ± 6.5

82.3 ± 4.0##

69.5 ± 3.5*

67.2 ± 2.9*

  1. Data are expressed as the mean ± standard error (n = 8)
  2. #p < 0.05
  3. ##p < 0.01
  4. ###p < 0.001 vs. WT mice
  5. *p < 0.05
  6. **p < 0.01
  7. ***p < 0.001 vs. APP/PS1 mice
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Journal of Neuroinflammation

ISSN: 1742-2094