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Fig. 2 | Journal of Neuroinflammation

Fig. 2

From: A new mouse model to study restoration of interleukin-6 (IL-6) expression in a Cre-dependent manner: microglial IL-6 regulation of experimental autoimmune encephalomyelitis

Fig. 2

IL6-DIO-KO mice are resistant to EAE. a Left: Weight loss of WT and IL6-DIO-KO mice after being immunized with MOG35–55 peptide. Right: Clinical evaluation of MOG35-55-immunized WT and IL6-DIO-KO mice. IL6-DIO-KO mice did not develop EAE-related symptoms. b Clinical evaluation of EAE. A significant effect on the disease onset, time to peak disease, peak score, and median score between WT and IL6-DIO-KO mice was observed. The incidence, disease onset, and time to peak were calculated using a clinical score ≥1. c Serum IL-6 protein levels were not detected in IL6-DIO-KO mice at 19 dpi. d Heatmap of IL-6 ELISA levels and the respective AUC for each animal in the experiment. Mice with higher disease scores also showed higher IL-6 levels. It is also clear that the two WT mice that did not develop clinical symptoms also did not have increased IL-6 levels. All results are represented as mean ± SEM; p ≤ 0.05 vs. MOG-WT mice

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