Skip to main content
Fig. 4 | Journal of Neuroinflammation

Fig. 4

From: A new mouse model to study restoration of interleukin-6 (IL-6) expression in a Cre-dependent manner: microglial IL-6 regulation of experimental autoimmune encephalomyelitis

Fig. 4

Reactivation of microglia-derived Il6 expression in IL6-DIO-ONCx3cr1 mice. a Serum IL-6 protein levels of LPS-injected IL6-DIO-Het, IL6-DIO-ONCx3cr1 and IL6-DIO-KO mice 1 day following 11 days of TAM treatment. b Left: IL6-DIO-ONCx3cr1 and IL6-DIO-KO mice were euthanized 1 month after TAM treatment and the brains were homogenized and incubated with CD11b+ antibody. Besides, the positive cell population was selected using columns with ferromagnetic spheres. Right: The reversion band (463 bp) was only seen in the brain CD11b+ fraction of IL6-DIO-ONCx3cr1 mice. All results are represented as mean ± SEM

Back to article page

Journal of Neuroinflammation

ISSN: 1742-2094