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Fig. 5 | Journal of Neuroinflammation

Fig. 5

From: A new mouse model to study restoration of interleukin-6 (IL-6) expression in a Cre-dependent manner: microglial IL-6 regulation of experimental autoimmune encephalomyelitis

Fig. 5

IL6-DIO-ONCx3cr1 showed mild EAE-related symptoms. a Clinical course of MOG-IL6-DIO-Het, MOG-IL6-DIO-ONCx3cr1 and MOG-IL6-DIO-KO mice. Body weight (left) and clinical signs (middle) changes were observed in IL6-DIO-Het and IL6-DIO-ONCx3cr1 mice whereas IL6-DIO-KO mice were almost completely resistant to EAE. Area under the curve (AUC; right) was calculated from EAE clinical course for each mouse between days 21 and 27. b Clinical evaluation of EAE. IL6-DIO-ONCx3cr1 and IL6-DIO-KO mice were significantly less affected than IL6-DIO-Het mice. The incidence, disease onset, and time to peak were calculated using a clinical score ≥1. Results in (a) are represented as mean ± SEM, while (b) shows median and IQR (except for incidence and mortality). NA (not applicable) shows the impossibility to calculate the median (given the criterion for disease). p ≤ 0.05 vs. MOG-IL6-DIO-Het mice

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