Fig. 6
Inflammation-related genes are down-regulated accordingly to disease severity. The changes of inflammation-related genes expression were studied using the upper part of the spinal cord (segments C1–T11) of three groups of mice euthanized at 27 dpi. a Gene expression of Il6, Il17a, Foxp3, and Rorc was lower in MOG-IL6-DIO-ONCx3cr1 and MOG-IL6-DIO-KO mice than in MOG-IL6-DIO-Het control mice. b Heatmap of Il6 expression and AUC of disease score. Il6 was only increased in mice with higher AUC. Results in (a) are represented as mean ± SEM; ★p ≤ 0.05 vs. MOG-IL6-DIO-Het mice