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Fig. 7 | Journal of Neuroinflammation

Fig. 7

From: A new mouse model to study restoration of interleukin-6 (IL-6) expression in a Cre-dependent manner: microglial IL-6 regulation of experimental autoimmune encephalomyelitis

Fig. 7

Demyelination was mildly affected by the recovery of microglial IL-6 at 27 dpi. Representative images of LFB/H&E staining and percentage of demyelination in the white matter of the spinal cord from BSA-immunized IL6-DIO-Het and MOG35-55-immunized IL6-DIO-Het, IL6-DIO-ONCx3cr1, and IL6-DIO-KO mice. A prominent accumulation of cells was shown in MOG-IL6-DIO-Het mice, and to a lesser extent in MOG-IL6-DIO-ONCx3cr1 mice. The contrast of the representative images was enhanced. The discontinuous line delimits white matter (WM) from gray matter (GM). Scale bar: 100 μm. Results were normalized to the total area and are represented as mean ± SEM; p ≤ 0.05 vs. BSA-IL6-DIO-Het mice; p ≤ 0.05 vs. MOG-IL6-DIO-Het mice

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