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Fig. 4 | Journal of Neuroinflammation

Fig. 4

From: Knockdown of long non-coding RNA SOX2OT downregulates SOX2 to improve hippocampal neurogenesis and cognitive function in a mouse model of sepsis-associated encephalopathy

Fig. 4

SOX2OT knockdown attenuated sepsis-induced cognitive dysfunction in mice with sepsis-associated encephalopathy. a Escape latency, b swimming speed, c time spent in the target quadrant, d number of times mice crossing the target quadrant, and e representative swim paths on the test day in the Morris water maze. The white circle indicates the location of the training platform, which was removed during the test. f Freezing time in context and g freezing time in response to a cue in the fear conditioning test (n = 16/group). &p < 0.05 vs. day 1 of Morris water maze test; *p < 0.05 vs. Sham; #p < 0.05 vs. CLP; ^^p < 0.01. Abbreviations: CLP, cecal ligation and perforation; si-CRTL, scrambled control siRNA; si-SOX2OT, SOX2OT siRNA

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Journal of Neuroinflammation

ISSN: 1742-2094