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Fig. 5 | Journal of Neuroinflammation

Fig. 5

From: Knockdown of long non-coding RNA SOX2OT downregulates SOX2 to improve hippocampal neurogenesis and cognitive function in a mouse model of sepsis-associated encephalopathy

Fig. 5

SOX2OT knockdown using siRNA attenuated the loss of cell proliferation and mature neurons, and reduced glial differentiation in the hippocampus of mice with sepsis-associated encephalopathy. Representative immunofluorescence micrographs showing (a) BrdU+/DCX+ cells, (b) BrdU+/GFAP+ glial cells and (c) BrdU+/NeuN+ neurons in the dentate gyrus of the hippocampus from CLP mice injected with SOX2OT siRNA. Magnification: × 200. Scale bar = 100 μm. Quantification of immunofluorescent cells staining positive for (d) BrdU/DCX, (e) BrdU/GFAP or (f) BrdU/NeuN. *p < 0.05; **p < 0.01. Abbreviations: CLP, cecal ligation and perforation; si-CRTL; scrambled control siRNA; si-SOX2OT, SOX2OT siRNA

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