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Fig. 8 | Journal of Neuroinflammation

Fig. 8

From: Knockdown of long non-coding RNA SOX2OT downregulates SOX2 to improve hippocampal neurogenesis and cognitive function in a mouse model of sepsis-associated encephalopathy

Fig. 8

SOX2 knockdown using siRNA alleviated sepsis-induced cognitive dysfunction in sepsis-associated encephalopathy mice. a Escape latency, b swimming speed, c time spent in the target quadrant, and d number of times mice crossed the target quadrant on the test day in the Morris water maze. e Freezing time to context and f freezing time to cue in the fear conditioning test (n = 16/group). &p < 0.05 vs. day 1 of Morris water maze test; *p < 0.05 vs. Sham; #p < 0.05 vs. CLP; ^p < 0.05; ^^p < 0.01. Abbreviations: CLP, cecal ligation and perforation; si-CRTL, scrambled control siRNA; si-SOX2, SOX2 siRNA

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