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Fig. 7 | Journal of Neuroinflammation

Fig. 7

From: Escalating morphine dosing in HIV-1 Tat transgenic mice with sustained Tat exposure reveals an allostatic shift in neuroinflammatory regulation accompanied by increased neuroprotective non-endocannabinoid lipid signaling molecules and amino acids

Fig. 7

Morphine treatment increased 2-LG, OEA, PEA, and SEA concentrations (pg/mg) in the striatum but not spinal cord of Tat transgenic mice. Concentrations of 2-AG and AEA and other lipid molecules were assessed in the striatum and spinal cord on saline and morphine-treated Tat transgenic mice using LC/MS/MS. Lipid concentrations were normalized to pg/mg of tissue. a In the striatum, morphine significantly upregulated 2-LG, OEA, PEA, and SEA concentrations in Tat(+) and Tat(−) mice. b In the spinal cord, no significant effects were noted on any of the 4 measures. All data are expressed as mean ± SEM. Statistical significance was assessed by ANOVA followed by Tukey’s post hoc test; *p < 0.05 main effect of drug. Morph short-term (8-day) morphine injections. n = 3–5 mice per group

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Journal of Neuroinflammation

ISSN: 1742-2094