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Fig. 2 | Journal of Neuroinflammation

Fig. 2

From: Chronic alcohol-induced neuroinflammation involves CCR2/5-dependent peripheral macrophage infiltration and microglia alterations

Fig. 2

Alcohol-induced peripheral macrophages differentially infiltrate the CNS. a CX3CR1eGFP/+ CCR2RFP/+ mice were generated by crossing CX3CR1eGFP/eGFP CCR2+/+ and CX3CR1+/+ CCR2RFP/RFP mice to allow visualization of resident microglia (GFP+; green) and brain infiltrating macrophages (RFP+; red) in the cortex, cerebellum, and hippocampus of mice fed chronic alcohol or a calorie-matched diet. b Acquired × 10 images of ethanol-fed CX3CR1eGFP/+ CCR2RFP/+ mice were stitched together to provide the larger representative images shown. c, d Quantification of resident CX3CR1-eGFP+ microglia and CCR2-RFP+ brain infiltrating macrophages in the cortex, cerebellum, and hippocampus. Data are mean ± SEM, n = 4–7 mice/group. *p < 0.05; n.s., not significant by Student’s t test

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