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Fig. 5 | Journal of Neuroinflammation

Fig. 5

From: Chronic alcohol-induced neuroinflammation involves CCR2/5-dependent peripheral macrophage infiltration and microglia alterations

Fig. 5

Alcohol-induced morphologic changes in microglia are partially restored by CCR2/5 inhibition. a Representative images of hippocampal microglia (CX3CR1-GFP+; green) displaying altered morphologies in pair-fed (PF) vs alcohol-fed (EtOH) mice, acquired at × 63 magnification. b Quantification of average hippocampal microglia soma area (pixel2) and c perimeter distance (pixel length) in mice fed control or alcohol diet or alcohol-fed mice treated with CCR2/5 inhibitor. d Expression of various activation markers were measured by flow cytometry in CD11b+ CD45lo microglia including CD86, CD68, MHC-II, CD163, and CD206. Data are mean ± SEM, n = 3 mice/group and 3–10 sections/mouse for ac and n = 6–7 mice/group for d. *p < 0.05 by one-way ANOVA.

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