Cortex
|
---|
|
PF
|
EtOH
|
PF vs EtOH
|
EtOH + 6wk CVC
|
EtOH vs 6 weeks
|
EtOH + 3wk CVC
|
EtOH vs 3 weeks, p value
|
---|
Mean
|
Stdev
|
Mean
|
Stdev
|
p value
|
Mean
|
Stdev
|
p value
|
Mean
|
Stdev
|
---|
Nanostring
|
C1qa
|
1.021
|
0.242
|
1.472
|
0.519
|
0.089
|
0.751
|
0.185
|
*0.012
|
0.750
|
0.265
|
*0.015
|
C1qb
|
1.015
|
0.196
|
1.016
|
0.292
|
0.996
|
0.959
|
0.272
|
0.797
|
0.882
|
0.243
|
0.426
|
Ccl11
|
1.156
|
0.743
|
14.52
|
12.66
|
0.073
|
4.626
|
3.510
|
*0.036
|
3.333
|
3.057
|
0.062
|
Daxx
|
1.020
|
0.219
|
1.331
|
0.303
|
0.080
|
0.751
|
0.108
|
*< 0.001
|
0.890
|
0.294
|
*0.038
|
Gnas
|
1.017
|
0.218
|
1.167
|
0.279
|
0.342
|
0.734
|
0.068
|
*< 0.01
|
0.687
|
0.173
|
*< 0.01
|
Hmgn1
|
1.004
|
0.099
|
1.167
|
0.307
|
0.247
|
1.086
|
0.157
|
0.508
|
0.960
|
0.244
|
0.243
|
Hspb1
|
1.017
|
0.204
|
1.275
|
0.143
|
*0.042
|
1.034
|
0.238
|
0.124
|
0.937
|
0.237
|
*0.021
|
Il23
|
1.584
|
1.547
|
0.926
|
0.657
|
0.401
|
2.484
|
2.326
|
0.222
|
2.430
|
0.941
|
*0.015
|
Itgb2
|
1.103
|
0.498
|
0.833
|
0.447
|
0.394
|
0.384
|
0.203
|
0.123
|
0.726
|
0.621
|
0.771
|
Map3k9
|
1.068
|
0.459
|
0.825
|
0.422
|
0.389
|
0.645
|
0.427
|
0.433
|
0.576
|
0.180
|
0.219
|
Mapk1
|
1.075
|
0.499
|
1.258
|
0.269
|
0.482
|
0.820
|
0.397
|
0.108
|
0.843
|
0.267
|
*0.031
|
Mef2a
|
1.019
|
0.205
|
0.913
|
0.210
|
0.420
|
1.093
|
0.384
|
0.402
|
1.072
|
0.391
|
0.437
|
Myd88
|
1.017
|
0.200
|
0.968
|
0.244
|
0.720
|
1.096
|
0.263
|
0.596
|
0.931
|
0.108
|
0.750
|
Plcb1
|
1.002
|
0.070
|
0.894
|
0.188
|
0.223
|
0.74
|
0.090
|
0.231
|
0.824
|
0.126
|
0.474
|
Tgfβ1
|
1.023
|
0.236
|
1.474
|
0.422
|
0.052
|
0.839
|
0.450
|
*0.038
|
0.657
|
0.194
|
*< 0.01
|
Proinflammatory
|
Tnfα
|
1.135
|
0.651
|
2.597
|
1.694
|
0.081
|
2.085
|
1.196
|
0.530
|
0.782
|
0.796
|
*0.043
|
Il1β
|
1.231
|
0.757
|
1.19
|
0.403
|
0.916
|
0.667
|
0.235
|
0.061
|
1.145
|
0.667
|
0.899
|
Il17
|
1.180
|
0.696
|
0.823
|
0.279
|
0.312
|
1.975
|
0.695
|
*0.018
|
1.676
|
1.170
|
0.149
|
Tlr4
|
1.023
|
0.236
|
1.209
|
0.492
|
0.430
|
1.024
|
0.409
|
0.678
|
1.013
|
0.309
|
0.439
|
Cox2
|
1.010
|
0.153
|
1.265
|
0.229
|
0.054
|
1.096
|
0.317
|
0.434
|
1.234
|
0.139
|
0.788
|
Ym1
|
1.093
|
0.412
|
22.40
|
13.11
|
*< 0.01
|
8.849
|
9.192
|
*0.013
|
8.183
|
7.048
|
*0.041
|
CCR2/5 network
|
Ccl2
|
1.187
|
0.633
|
0.960
|
0.221
|
0.524
|
2.227
|
0.552
|
*< 0.01
|
1.684
|
1.458
|
0.364
|
Ccl3
|
1.311
|
0.821
|
2.090
|
1.527
|
0.307
|
1.909
|
1.716
|
0.764
|
1.549
|
1.033
|
0.502
|
Ccr2
|
1.065
|
0.402
|
0.764
|
0.165
|
0.200
|
1.214
|
1.718
|
0.623
|
1.256
|
0.564
|
0.134
|
Ccr5
|
1.019
|
0.223
|
1.530
|
0.412
|
*0.027
|
1.081
|
0.378
|
0.060
|
1.296
|
0.518
|
0.436
|
- Gene expression was measured by qPCR. Data are mean or standard deviation (Stdev), n = 5–6 mice/group
- *p < 0.05 and significant p values are offset from non-significant values