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Table 3 Gene expression profile of the cortex

From: Chronic alcohol-induced neuroinflammation involves CCR2/5-dependent peripheral macrophage infiltration and microglia alterations

Cortex
  PF EtOH PF vs EtOH EtOH + 6wk CVC EtOH vs 6 weeks EtOH + 3wk CVC EtOH vs 3 weeks, p value
Mean Stdev Mean Stdev p value Mean Stdev p value Mean Stdev
Nanostring
 C1qa 1.021 0.242 1.472 0.519 0.089 0.751 0.185 *0.012 0.750 0.265 *0.015
 C1qb 1.015 0.196 1.016 0.292 0.996 0.959 0.272 0.797 0.882 0.243 0.426
 Ccl11 1.156 0.743 14.52 12.66 0.073 4.626 3.510 *0.036 3.333 3.057 0.062
 Daxx 1.020 0.219 1.331 0.303 0.080 0.751 0.108 *< 0.001 0.890 0.294 *0.038
 Gnas 1.017 0.218 1.167 0.279 0.342 0.734 0.068 *< 0.01 0.687 0.173 *< 0.01
 Hmgn1 1.004 0.099 1.167 0.307 0.247 1.086 0.157 0.508 0.960 0.244 0.243
 Hspb1 1.017 0.204 1.275 0.143 *0.042 1.034 0.238 0.124 0.937 0.237 *0.021
 Il23 1.584 1.547 0.926 0.657 0.401 2.484 2.326 0.222 2.430 0.941 *0.015
 Itgb2 1.103 0.498 0.833 0.447 0.394 0.384 0.203 0.123 0.726 0.621 0.771
 Map3k9 1.068 0.459 0.825 0.422 0.389 0.645 0.427 0.433 0.576 0.180 0.219
 Mapk1 1.075 0.499 1.258 0.269 0.482 0.820 0.397 0.108 0.843 0.267 *0.031
 Mef2a 1.019 0.205 0.913 0.210 0.420 1.093 0.384 0.402 1.072 0.391 0.437
 Myd88 1.017 0.200 0.968 0.244 0.720 1.096 0.263 0.596 0.931 0.108 0.750
 Plcb1 1.002 0.070 0.894 0.188 0.223 0.74 0.090 0.231 0.824 0.126 0.474
 Tgfβ1 1.023 0.236 1.474 0.422 0.052 0.839 0.450 *0.038 0.657 0.194 *< 0.01
Proinflammatory
 Tnfα 1.135 0.651 2.597 1.694 0.081 2.085 1.196 0.530 0.782 0.796 *0.043
 Il1β 1.231 0.757 1.19 0.403 0.916 0.667 0.235 0.061 1.145 0.667 0.899
 Il17 1.180 0.696 0.823 0.279 0.312 1.975 0.695 *0.018 1.676 1.170 0.149
 Tlr4 1.023 0.236 1.209 0.492 0.430 1.024 0.409 0.678 1.013 0.309 0.439
 Cox2 1.010 0.153 1.265 0.229 0.054 1.096 0.317 0.434 1.234 0.139 0.788
 Ym1 1.093 0.412 22.40 13.11 *< 0.01 8.849 9.192 *0.013 8.183 7.048 *0.041
CCR2/5 network
 Ccl2 1.187 0.633 0.960 0.221 0.524 2.227 0.552 *< 0.01 1.684 1.458 0.364
 Ccl3 1.311 0.821 2.090 1.527 0.307 1.909 1.716 0.764 1.549 1.033 0.502
 Ccr2 1.065 0.402 0.764 0.165 0.200 1.214 1.718 0.623 1.256 0.564 0.134
 Ccr5 1.019 0.223 1.530 0.412 *0.027 1.081 0.378 0.060 1.296 0.518 0.436
  1. Gene expression was measured by qPCR. Data are mean or standard deviation (Stdev), n = 5–6 mice/group
  2. *p < 0.05 and significant p values are offset from non-significant values
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