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Table 4 Gene expression profile of the hippocampus

From: Chronic alcohol-induced neuroinflammation involves CCR2/5-dependent peripheral macrophage infiltration and microglia alterations

Hippocampus
  PF EtOH PF vs EtOH EtOH + 6wk CVC EtOH vs 6 weeks EtOH + 3wk CVC EtOH vs 3 weeks, p value
Mean Stdev Mean Stdev p value Mean Stdev p value Mean Stdev
Nanostring
 C1qa 1.059 0.351 1.049 0.411 0.966 0.851 0.265 0.344 0.670 0.235 0.078
 C1qb 1.009 0.150 1.462 0.147 *< 0.001 1.782 0.459 0.134 1.563 0.265 0.431
 Ccl11 1.156 0.743 14.52 12.66 0.073 4.626 3.510 0.095 3.333 3.057 0.062
 Daxx 1.029 0.261 0.821 0.398 0.310 0.733 0.217 0.645 0.622 0.253 0.327
 Gnas 1.017 0.208 0.585 0.306 *0.017 0.613 0.100 0.834 0.492 0.226 0.563
 Hmgn1 1.017 0.213 1.482 0.333 *0.016 1.302 0.213 0.291 1.485 0.645 0.993
 Hspb1 1.044 0.322 1.357 0.432 0.185 1.274 0.278 0.703 1.013 0.283 0.134
 Il23 1.804 1.911 10.62 5.981 *< 0.01 3.780 4.233 *0.045 3.099 3.019 *0.020
 Itgb2 1.225 0.749 0.632 0.254 0.097 1.340 0.601 *0.024 0.913 0.471 0.227
 Map3k9 1.073 0.414 2.298 1.428 0.071 1.533 0.443 0.239 1.079 0.293 0.068
 Mapk1 1.087 0.409 1.033 0.242 0.785 1.041 0.570 0.976 0.887 0.251 0.329
 Mef2a 1.022 0.233 1.636 0.702 0.070 1.577 0.183 0.846 1.784 0.349 0.653
 Myd88 1.029 0.263 1.379 0.285 0.052 1.222 0.272 0.354 1.022 0.209 *0.033
 Plcb1 1.087 0.438 1.685 0.307 *0.021 1.724 0.328 0.837 1.742 0.191 0.708
 Tgfβ1 1.039 0.302 0.946 0.344 0.630 0.982 0.342 0.858 0.488 0.312 *0.036
Proinflammatory
 Tnfα 1.246 0.651 2.206 1.911 0.291 1.490 0.665 0.407 1.383 1.214 0.394
 Il1β 2.320 0.757 2.587 1.707 0.853 1.622 0.811 0.239 1.570 0.866 0.222
 Il17 1.069 0.696 1.017 0.534 0.859 1.652 0.745 0.121 1.213 0.769 0.620
 Tlr4 1.047 0.236 1.772 0.856 0.083 1.773 0.891 0.999 1.496 0.728 0.562
 Cox2 1.007 0.153 1.011 0.168 0.970 1.275 0.231 *0.047 1.325 0.257 *0.031
 Ym1 1.093 0.412 22.40 13.11 *< 0.01 8.849 9.192 0.084 8.183 7.048 *0.041
CCR2/5 network
 Ccl2 1.051 0.633 3.926 2.837 *0.034 3.858 2.162 0.963 1.451 1.033 0.072
 Ccl3 1.301 0.821 6.713 3.069 *< 0.01 2.188 1.338 *< 0.01 2.737 2.238 *0.035
 Ccr2 1.024 0.402 11.67 6.247 *0.010 3.958 3.253 *0.035 2.955 2.310 *< 0.01
 Ccr5 1.024 0.223 3.433 1.685 *< 0.01 1.659 0.404 *0.031 2.267 0.733 0.151
  1. Gene expression was measured by qPCR. Data are mean or standard deviation (Stdev), n = 5–6 mice/group
  2. *p < 0.05 and significant p values are offset from non-significant values