|
Cerebellum
|
|---|
| |
PF
|
EtOH
|
PF vs EtOH
|
EtOH + 6wk CVC
|
EtOH vs 6 weeks
|
EtOH + 3wk CVC
|
EtOH vs 3 weeks, p value
|
|---|
|
Mean
|
Stdev
|
Mean
|
Stdev
|
p value
|
Mean
|
Stdev
|
p value
|
Mean
|
Stdev
|
|---|
|
Nanostring
|
|
C1qa
|
1.079
|
0.47
|
2.788
|
1.243
|
*0.010
|
1.942
|
0.872
|
0.202
|
1.266
|
0.786
|
*0.030
|
|
C1qb
|
1.012
|
0.161
|
1.017
|
0.397
|
0.976
|
0.773
|
0.275
|
0.244
|
1.165
|
0.264
|
0.466
|
|
Ccl11
|
1.043
|
0.326
|
37.22
|
36.99
|
0.060
|
16.70
|
26.98
|
0.315
|
6.682
|
12.75
|
0.119
|
|
Daxx
|
1.015
|
0.182
|
0.972
|
0.265
|
0.750
|
1.132
|
0.524
|
0.519
|
0.704
|
0.214
|
0.083
|
|
Gnas
|
1.014
|
0.198
|
0.713
|
0.401
|
0.130
|
0.842
|
0.269
|
0.528
|
0.611
|
0.160
|
0.577
|
|
Hmgn1
|
1.196
|
0.977
|
2.302
|
1.353
|
0.136
|
1.531
|
0.486
|
0.219
|
1.183
|
1.154
|
0.155
|
|
Hspb1
|
1.167
|
0.733
|
2.995
|
1.489
|
*0.022
|
1.916
|
0.724
|
0.141
|
1.007
|
0.683
|
*0.014
|
|
Il23
|
1.277
|
1.110
|
2.449
|
1.791
|
0.203
|
2.278
|
0.849
|
0.836
|
1.032
|
1.011
|
0.122
|
|
Itgb2
|
1.034
|
0.286
|
2.150
|
1.830
|
0.169
|
1.024
|
0.868
|
0.221
|
1.501
|
1.000
|
0.516
|
|
Map3k9
|
1.220
|
0.987
|
3.344
|
2.486
|
0.080
|
2.916
|
1.733
|
0.736
|
1.033
|
1.249
|
0.069
|
|
Mapk1
|
1.462
|
1.768
|
1.327
|
0.595
|
0.862
|
1.257
|
0.473
|
0.826
|
1.644
|
1.290
|
0.602
|
|
Mef2a
|
1.094
|
0.584
|
1.249
|
0.160
|
0.544
|
1.232
|
0.317
|
0.906
|
0.715
|
0.525
|
*0.039
|
|
Myd88
|
1.072
|
0.470
|
1.020
|
0.538
|
0.863
|
1.398
|
0.607
|
0.281
|
1.358
|
0.222
|
0.186
|
|
Plcb1
|
1.004
|
0.098
|
0.995
|
0.390
|
0.955
|
1.324
|
0.370
|
0.164
|
1.313
|
0.337
|
0.161
|
|
Tgfβ1
|
1.027
|
0.257
|
0.997
|
0.641
|
0.918
|
0.697
|
0.466
|
0.376
|
0.698
|
0.363
|
0.343
|
|
Proinflammatory
|
|
Tlr4
|
1.151
|
0.368
|
1.813
|
1.143
|
0.207
|
1.164
|
0.450
|
0.225
|
1.406
|
0.710
|
0.477
|
|
Cox2
|
1.028
|
0.270
|
1.116
|
0.319
|
0.620
|
1.311
|
0.350
|
0.336
|
1.646
|
0.638
|
0.099
|
|
Ym1
|
2.022
|
2.479
|
3.953
|
4.398
|
0.371
|
3.755
|
6.046
|
0.951
|
3.598
|
2.942
|
0.873
|
|
CCR2/5 network
|
|
Ccl2
|
1.087
|
0.471
|
7.654
|
6.998
|
0.068
|
3.831
|
2.432
|
0.235
|
3.102
|
3.328
|
0.181
|
|
Ccl3
|
1.643
|
1.988
|
4.614
|
4.774
|
0.229
|
1.042
|
1.473
|
0.145
|
1.452
|
1.565
|
0.193
|
|
Ccr2
|
1.047
|
0.384
|
21.35
|
24.06
|
0.096
|
10.48
|
13.49
|
0.368
|
4.777
|
8.151
|
0.234
|
|
Ccr5
|
1.039
|
0.280
|
2.190
|
0.530
|
*< 0.001
|
1.185
|
0.524
|
*< 0.01
|
1.819
|
1.235
|
0.514
|
- Gene expression was measured by qPCR. Data are mean or standard deviation (Stdev), n = 5–6 mice/group
- *p < 0.05 and significant p values are offset from non-significant values
