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Table 5 Gene expression profile of the cerebellum

From: Chronic alcohol-induced neuroinflammation involves CCR2/5-dependent peripheral macrophage infiltration and microglia alterations

Cerebellum
  PF EtOH PF vs EtOH EtOH + 6wk CVC EtOH vs 6 weeks EtOH + 3wk CVC EtOH vs 3 weeks, p value
Mean Stdev Mean Stdev p value Mean Stdev p value Mean Stdev
Nanostring
 C1qa 1.079 0.47 2.788 1.243 *0.010 1.942 0.872 0.202 1.266 0.786 *0.030
 C1qb 1.012 0.161 1.017 0.397 0.976 0.773 0.275 0.244 1.165 0.264 0.466
 Ccl11 1.043 0.326 37.22 36.99 0.060 16.70 26.98 0.315 6.682 12.75 0.119
 Daxx 1.015 0.182 0.972 0.265 0.750 1.132 0.524 0.519 0.704 0.214 0.083
 Gnas 1.014 0.198 0.713 0.401 0.130 0.842 0.269 0.528 0.611 0.160 0.577
 Hmgn1 1.196 0.977 2.302 1.353 0.136 1.531 0.486 0.219 1.183 1.154 0.155
 Hspb1 1.167 0.733 2.995 1.489 *0.022 1.916 0.724 0.141 1.007 0.683 *0.014
 Il23 1.277 1.110 2.449 1.791 0.203 2.278 0.849 0.836 1.032 1.011 0.122
 Itgb2 1.034 0.286 2.150 1.830 0.169 1.024 0.868 0.221 1.501 1.000 0.516
 Map3k9 1.220 0.987 3.344 2.486 0.080 2.916 1.733 0.736 1.033 1.249 0.069
 Mapk1 1.462 1.768 1.327 0.595 0.862 1.257 0.473 0.826 1.644 1.290 0.602
 Mef2a 1.094 0.584 1.249 0.160 0.544 1.232 0.317 0.906 0.715 0.525 *0.039
 Myd88 1.072 0.470 1.020 0.538 0.863 1.398 0.607 0.281 1.358 0.222 0.186
 Plcb1 1.004 0.098 0.995 0.390 0.955 1.324 0.370 0.164 1.313 0.337 0.161
 Tgfβ1 1.027 0.257 0.997 0.641 0.918 0.697 0.466 0.376 0.698 0.363 0.343
Proinflammatory
 Tlr4 1.151 0.368 1.813 1.143 0.207 1.164 0.450 0.225 1.406 0.710 0.477
 Cox2 1.028 0.270 1.116 0.319 0.620 1.311 0.350 0.336 1.646 0.638 0.099
 Ym1 2.022 2.479 3.953 4.398 0.371 3.755 6.046 0.951 3.598 2.942 0.873
CCR2/5 network
 Ccl2 1.087 0.471 7.654 6.998 0.068 3.831 2.432 0.235 3.102 3.328 0.181
 Ccl3 1.643 1.988 4.614 4.774 0.229 1.042 1.473 0.145 1.452 1.565 0.193
 Ccr2 1.047 0.384 21.35 24.06 0.096 10.48 13.49 0.368 4.777 8.151 0.234
 Ccr5 1.039 0.280 2.190 0.530 *< 0.001 1.185 0.524 *< 0.01 1.819 1.235 0.514
  1. Gene expression was measured by qPCR. Data are mean or standard deviation (Stdev), n = 5–6 mice/group
  2. *p < 0.05 and significant p values are offset from non-significant values