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Fig. 8 | Journal of Neuroinflammation

Fig. 8

From: Inhibiting HMGB1-RAGE axis prevents pro-inflammatory macrophages/microglia polarization and affords neuroprotection after spinal cord injury

Fig. 8

Inhibiting RAGE by FPS-ZM1 reduced myelin loss after SCI. a Spinal cords at 21 days after injury were processed for Luxol fast blue in saline- or FPS-ZM1-treated rats. Transverse cryosections were selected 1000 μm, 2000 μm rostral and caudal to the lesion site, and the epicenter. b Quantification of spared myelin at 1000 μm, 2000 μm rostral and caudal to the lesion site, as well as at the epicenter. Data were expressed as mean ± SEM of 6 rats, *P < 0.05. c DAB staining of MBP in transverse sections at 21 dpi. Scale bar = 100 μm. d Quantification of MBP intensity. Note that FPS-ZM1 attenuated the reduction of MBP intensity in the white matter after injury. Data were expressed as mean ± SEM of 6 rats, *P < 0.05, **P < 0.01. ef Quantification of the protein expression level of MBP in sham group, saline-, or FPS-ZM1-treated rats at 21 days after SCI. N = 6/group, *P < 0.05, **P < 0.01

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