Fig. 6

VB protected APP/PS1 mice against ER stress. VB reduced the concentrations of the following proteins related to ER stress in mice brains by ELISA: a MANF, b BiP, c ATF6, d p-IRE1/IRE1, e XBP1, f p-PERK/PERK, g p-eIF2α/eIF2α, h ATF4, i CHOP, and j caspase 12. The data are presented as mean ± SEM (n = 8/group). ^#p < 0.05, ^##p < 0.01, and ^###p < 0.001 vs. WT mice, *p < 0.05 and ***p < 0.001 vs. APP/PS1 mice