Fig. 7
VB attenuated ER stress in APP/PS1 mice and Aβ1-42-exposed U251 cells. VB reduced the expression levels of MANF, BiP, ATF6, XBP1s, ATF4, CHOP, and caspase 12 and the levels of phosphorylated IRE1, PERK, and eIF2α in a the brain lysates of APP/PS1 mice and b Aβ1-42-exposed U251 cells. GAPDH was used as a loading control and for band-density normalization. Phosphorylated proteins were normalized using the related total protein concentration. The data are presented as means ± SEM (n = 4/group). #p < 0.05, ##p < 0.01, and ###p < 0.001 vs. WT mice or non-treated cells and *p < 0.05, **p < 0.01, and ***p < 0.001 vs. APP/PS1 mice or Aβ1-42-exposed cells