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Fig. 2 | Journal of Neuroinflammation

Fig. 2

From: Targeting connexin 43 provides anti-inflammatory effects after intracerebral hemorrhage injury by regulating YAP signaling

Fig. 2

Gap19 blocks Cx43Hc opening and provides neuroprotection after ICH injury. a, b EtBr staining evaluation showed that TAT-Gap19 treatment after ICH reduced Hc opening. c, d The TAT-Gap19 ICH group exhibited significantly fewer apoptotic neurons than the ICH group. e, f TAT-Gap19 treatment reduced hematoma volumes after ICH and increased the surviving blue-stained area. g TAT-Gap19 treatment significantly reduced post-ICH neurological dysfunction in mice, as assessed by mNSSs. h The balance beam test showed that after TAT-Gap19 treatment following ICH, the balance beam score, which reflected nerve function, was significantly reduced compared with that in the ICH group. i In the forelimb strength test, the grip strength of the ICH group was significantly lower than that of the TAT-Gap19 + ICH group. j In the foot fault test, the foot fault rate of the TAT-Gap19 + ICH group mice was significantly lower than that of the ICH group. The bars represent the SEM of the data from 3–6 brain tissue samples per group. *P < 0.05, **P < 0.01 compared to the sham group. #P < 0.05, ##P < 0.01 compared with the ICH group

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