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Fig. 3 | Journal of Neuroinflammation

Fig. 3

From: Tanshinone IIA attenuates neuroinflammation via inhibiting RAGE/NF-κB signaling pathway in vivo and in vitro

Fig. 3

Tan IIA reduces Aβ plaques and levels in APP/PS1 mice. a Representative immunohistochemistry (IHC) staining of MOAB2 (Aβ plaques) in the brain. Scale bar = 200 μm. b Quantitative analysis of Aβ IHC staining area in the parietal cortex and hippocampus. c Representative Th-S-positive Aβ plaques in the brain. Scale bar = 200 μm. d Quantitative analysis of Aβ Th-S staining area in the parietal cortex and hippocampus. eh The protein levels of soluble Aβ1–40 e, insoluble Aβ1–40 f, soluble Aβ1–42 g, and insoluble Aβ1–42 h in the parietal cortex and hippocampus. n = 5. Data were presented as mean ± SD. #p < 0.05 or ##p < 0.01 vs. WT group, and *p < 0.05 or **p < 0.01 vs. APP/PS1 group

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