Fig. 7

Effect of RAM-589.555 in-vivo on pre-rRNA transcript level in blood cells (a) and CNS’s resident glial cells; microglia (b) and astrocytes (c). On the day of disease onset (score 1), mice received RAM-589.555 by oral gavage. Mice were bled at day 7 after initial RAM-589.555 gavage as described in methods into heparinized tube; cells were lysed and further processed for qRT-PCR. Presented as fold change (FC) compare pre-rRNA transcript in healthy mice (n = 6 mice/group). The data presented are the mean ± SEM according to three independent experimental repeats. *p < 0.05 in RAM-589.555 vs. vehicle