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Table 2 Pharmacokinetic features of RAM-589.555 in blood and CNS of mice displaying EAE

From: RAM-589.555 favors neuroprotective and anti-inflammatory profile of CNS-resident glial cells in acute relapse EAE affected mice

25 mg/kg oral gavage

CNS

Plasma

Cmax ng/ml

251 ± 0.7

564 ± 78

Tmax, h

24

1.5 ± 0.3

AUC0-t, ng*h/ml

4897 ± 554.4

8048 ± 706.7