Fig. 1
From: Investigation of reactive astrogliosis effect on post-stroke cognitive impairment
Transforming the 18F-THK-5351 SUVR maps to 18F-THK-5351 Z-score maps. Regarding a representative healthy subject (a), off-target binding of 18F-THK-5351 to the basal ganglia and thalamus was noted on the SUVR maps (b, c). After transforming SUVR maps to Z-score maps, the signals in the basal ganglia and thalamus were robustly diminished (d). Regarding a patient with right hemisphere ischemic stroke (e), 18F-THK-5351 uptake signals were increased around the stroke lesion; further, they were asymmetrically elevated in the basal ganglia and thalamus on SUVR maps (f, g). On the Z-score map, the 18F-THK-5351 signals on the bilateral basal ganglia and thalamus were markedly suppressed and the stroke-induced 18F-THK-5351 uptake was better visualized (h)