Fig. 5
From: Endothelin-1 contributes to the development of virus-induced demyelinating disease
Effects of endothelin receptor antagonists on the development of TMEV-induced demyelinating disease. Mice (n = 5/group) were infected with TMEV (1 × 105 PFU) and were treated with PBS (cont), BQ610, or BQ788 (1 mg/kg) at days 0, 5, 10, 15, 20, 30, and 46. a Disease course was determined using the 5-point scale. Statistical significance was determined by two-tailed paired t test. b Proliferative responses and IFN-γ production by splenic T cells to UV-TMEV at 27 and 70 dpi. c Comparison of cytokine message levels in the CNS of treated mice at 27 dpi following RT-PCR. Data are presented as mean ± SEM of three independent experiments. *p < 0.05, **p < 0.001, and ***p < 0.0001