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Fig. 1 | Journal of Neuroinflammation

Fig. 1

From: Sestrin2 regulates microglia polarization through mTOR-mediated autophagic flux to attenuate inflammation during experimental brain ischemia

Fig. 1

Sestrin2 improved neurological functional recovery after tMCAO. a The timeline of the experimental protocol. b, c Bar graphs show the results of Clark and Longa neurological deficit scores at 1 day after tMCAO in Sham, NS, Sesn, and H-sesn groups. N = 10 per group. Data are presented as mean ± SEM, *p < 0.01, NS vs. Sesn. d Western blot and the quantification of FLAG-tagged sestrin2 expression in the Sesn-1dai and Sesn-3day groups. N = 3 per group. Data are presented as mean ± SEM, ***p < 0.001, NS vs. Sesn-1d, **p < 0.01, NS vs. Sesn-3d. e Representative images for cresyl violet staining of brain slices at 1day after tMCAO. f Quantification of adjusted infarction percentage based on the results of cresyl violet staining. N/A = not applicable. N = 10 per group. Data are presented as mean ± SEM, *p < 0.05, NS vs. Sesn, **p < 0.01, Sesn vs. H-Sesn

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