Fig. 2

Ldlr knockout aggravates post-stroke neurological deficits, brain edema, infarct progression, and neuronal degeneration. a Immunoblots and quantitative analysis of LDLR, n = 4 in each group. b Neurological scores assessment of mice in each group, n = 15. c Quantitative analysis of brain edema, n = 4. d, e Representative image of brain slices by TTC staining in each group 1 day after reperfusion and the quantitative analysis of infarct volume, n = 7. f FJC staining showed that the density of FJC-positive neurons was increased after MCAO and was further aggrandized by Ldlr deletion, n = 4. Insets show a higher magnification view. Scale bar = 50 μm. All results are displayed as mean ± SEM. *P < 0.05, ***P < 0.001 versus WT sham mice; ^#P < 0.05, ^##P < 0.01, ^###P < 0.001 versus WT MCAO mice