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Fig. 7 | Journal of Neuroinflammation

Fig. 7

From: Low-density lipoprotein receptor (LDLR) regulates NLRP3-mediated neuronal pyroptosis following cerebral ischemia/reperfusion injury

Fig. 7

Absence of LDLR fortifies neuronal inflammasome activation after OGD/R. a Representative immunofluorescence images and quantitative analysis of NLRP3, ASC, and caspase-1 in cultured neurons 24 h after reoxygenation, n = 4. Insets show a higher magnification view. Scale bar = 20 μm. bf Immunoblotting analysis and quantification of NLRP3, caspase-1, and IL-18 expressions in primary neurons, n = 5 for IL-18 and n = 4 for other proteins. All data are expressed as mean ± SEM. *P < 0.05, ***P < 0.001 versus WT control neurons; #P < 0.05 versus WT OGD neurons

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