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Fig. 8 | Journal of Neuroinflammation

Fig. 8

From: Low-density lipoprotein receptor (LDLR) regulates NLRP3-mediated neuronal pyroptosis following cerebral ischemia/reperfusion injury

Fig. 8

LDLR inhibition promotes NF-κB signaling activation. a, b Immunoblotting and quantitative analysis for p65, p-p65 in cerebral penumbra tissues, and cultured neurons, n = 4 for brain tissues and n = 3 for cultured neurons. c, d Real-time PCR for production of pro-IL-1β, pro-IL-18, and NLRP3 both in vivo and in vitro, n = 4–5. Data are shown as mean ± SEM. *P < 0.05, **P < 0.01, ***P < 0.001 versus WT sham or WT control group; #P < 0.05, ##P < 0.01 versus WT MCAO or WT OGD group

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