Fig. 6

Resveratrol reverses mechanical allodynia in SNI rats via enhancing TREM2-mediated autophagy. a Schematic of experimental procedures. b Representative Western blots and quantification of TREM2 in the ipsilateral SDH at 7 days in the Sham, SNI, and SNI + Lv-TREM2 rats. c The mRNA level of TREM2 in the ipsilateral SDH at 7 days in the Sham, SNI, and SNI + Lv-TREM2 rats. d, e The mechanical allodynia of the contralateral (d) and ipsilateral side (e) was detected by von Frey test at indicated time points in SNI, SNI + Res, SNI + Res + Lv-TREM2, SNI + Res + 3-MA, and SNI + Res + Lv-TREM2 + 3-MA group. Data were presented as mean ± SEM. n = 5 rats per group. The same color represented the same group. ***p < 0.001 vs. SNI + Res group, &&&p < 0.001 vs. SNI + Res + Lv-TREM2 group, ###p < 0.001 vs. SNI + Res + 3-MA. $p < 0.05 vs. SNI + Res + Lv-TREM2. f The 50% PWT in the ipsilateral side on day 7 from the five groups shown in (e). Data were presented as mean ± SEM. n = 6 rats per group; ***p < 0.001, **p < 0.01 vs. SNI group, &&&p < 0.001 vs. SNI + Res group, ###p < 0.001 vs. SNI + Res. $p < 0.05 vs. SNI + Res + Lv-TREM2