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Fig. 7 | Journal of Neuroinflammation

Fig. 7

From: Resveratrol mediates mechanical allodynia through modulating inflammatory response via the TREM2-autophagy axis in SNI rat model

Fig. 7

TREM2 or 3-MA reverses the anti-inflammation effects of resveratrol after SNI. a, b Representative blots and expression of TREM2, P62, LC3, IL-6, IL-1β, and TNF-α in the ipsilateral SDH at 7 days after SNI with i.t. resveratrol, Lv-TREM2, or 3-MA administration. c qPCR analysis of pro-inflammatory gene expression in the ipsilateral SDH at 7 days after SNI with i.t. resveratrol, Lv-TREM2, or 3-MA administration. d, e Representative blots and expression of IL-6, IL-1β, and TNF-α in the contralateral SDH at 7 days after SNI with i.t. resveratrol, Lv-TREM2, or 3-MA administration. f qPCR analysis of pro-inflammatory gene expression in the contralateral SDH at 7 days after SNI with i.t. resveratrol, Lv-TREM2, or 3-MA administration. Values were presented as the mean ± SEM. n = 6 per group. ***p < 0.001 vs. SNI group, &&&p < 0.001 vs. SNI + Res group, $$$p < 0.001 vs. SNI + Res group, ###p < 0.001 vs. SNI + Res + Lv-TREM2 group

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Journal of Neuroinflammation

ISSN: 1742-2094