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Fig. 4 | Journal of Neuroinflammation

Fig. 4

From: Cyclooxygenase-1 mediates neuroinflammation and neurotoxicity in a mouse model of retinitis pigmentosa

Fig. 4

COX-1 deletion preserves retinal function and visual performance in rd10 mice. a Statistical analysis of ERG amplitudes. Average scotopic a-wave and b-wave amplitudes elicited at 3 cd-s/m2 light intensity from WT, COX-1−/−, rd10, and COX-1−/−/rd10 mice at P25 (a wave: F(3, 20) = 47.79, p = 2.6 × 10−9; WT versus COX-1−/−, p = 0.66; WT versus rd10, p = 2.7 × 10−6; WT versus COX-1−/−/rd10, p = 0.00013; COX-1−/− versus rd10, p = 4.2 × 10−7; COX-1−/− versus COX-1−/−/rd10, p = 2.9 × 10−5; rd10 versus COX-1−/−/rd10, p = 0.00013. b wave: F(3, 20) = 52.58, p = 1.1 × 10−9; WT versus COX-1−/−, p = 0.99; WT versus rd10, p = 1.6 × 10−6; WT versus COX-1−/−/rd10, p = 0.00078; COX-1−/− versus rd10, p = 4.4 × 10−8; COX-1−/− versus COX-1−/−/rd10, p = 7.6 × 10−5; rd10 versus COX-1−/−/rd10, p = 1.7 × 10−5), and P30 (a wave: F(3, 20) = 192.48, p = 6.4 × 10−15; WT versus COX-1−/−, p = 0.21; WT versus rd10, p = 2.9 × 10−9; WT versus COX-1−/−/rd10, p = 6.0 × 10−8; COX-1−/− versus rd10, p = 5.2 × 10−10; COX-1−/− versus COX-1−/−/rd10, p = 3.0 × 10−8; rd10 versus COX-1−/−/rd10, p = 1.5 × 10−5. b wave: F(3, 20) = 167.63, p = 2.4 × 10−14; WT versus COX-1−/−, p = 0.98; WT versus rd10, p = 7.9 × 10−9; WT versus COX-1−/−/rd10, p = 3.6 × 10−6; COX-1−/− versus rd10, p = 4.6 × 10−10; COX-1−/− versus COX-1−/−/rd10, p = 1.8 × 10−7; rd10 versus COX-1−/−/rd10, p = 2.6 × 10−7). b Average photopic b-wave amplitudes elicited at 3 cd-s/m2 light intensity on P25 (F(3, 20) = 66.41, p = 1.4 × 10-10; WT versus COX-1−/−, p = 0.29; WT versus rd10, p = 1.6 × 10-7; WT versus COX-1−/−/rd10, p = 2.1 × 10−5; COX-1−/− versus rd10, p = 6.5 × 10−7; COX-1−/− versus COX-1−/−/rd10, p = 0.00015; rd10 versus COX-1−/−/rd10, p = 0.00013), and P30 WT, rd10 and COX-1−/−/rd10 mice (F (3, 20) = 226.35, p = 1.3 × 10−15; WT versus COX-1−/−, p = 0.43; WT versus rd10, p = 3.0 × 10−10; WT versus COX-1−/−/rd10, p = 1.7 × 10−7; COX-1−/− versus rd10, p = 2.5 × 10−10; COX-1−/− versus COX-1−/−/rd10, p = 2.6 × 10−7; rd10 versus COX-1−/−/rd10, p = 9.2 × 10−7). c Photopic visual acuity was evaluated from WT, COX-1−/−/, rd10 and COX-1−/−/rd10 mice at P25 (F(3, 20) = 88.99, p = 9.6 × 10−12; WT versus COX-1−/−, p = 0.14; WT versus rd10, p = 6.1 × 10−8; WT versus COX-1−/−/rd10, p = 2.0 × 10−5; COX-1−/− versus rd10, p = 7.2 × 10−8; COX-1−/− versus COX-1−/−/rd10, p = 5.9 × 10−5; rd10 versus COX-1−/−/rd10, p = 1.1 × 10−5), and P30 (F(3, 20) = 268.55, p = 2.5 × 10−16; WT versus COX-1−/−, p = 0.41; WT versus rd10, p = 4.4 × 10−10; WT versus COX-1−/−/rd10, p = 6.0 × 10−8; COX-1−/− versus rd10, p = 2.2 × 10−10; COX-1−/− versus COX-1−/−/rd10, p = 2.4 × 10−8; rd10 versus COX-1−/−/rd10, p = 1.1 × 10v6). Results are presented as means ± SDs (n = 6 animals/each group). ***p < 0.001

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