Fig. 4

Trends in microglia activation and neurological impairments following adolescent RmTBI. Throughout life, microglia are known to become increasingly activated. In addition, neurological impairments increase throughout adulthood and ageing. RmTBIs sustained in adolescence may cause earlier chronic or primed microglia activation that may persist into adulthood and through aging. Increased microglia activation during the adolescent developmental period may therefore influence the acquisition or onset of neurological impairments throughout life. Disruption to neurological functioning may induce negative consequences through adulthood into aging