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Fig. 4 | Journal of Neuroinflammation

Fig. 4

From: Role of macrophage-mediated Toll-like receptor 4–interleukin-1R signaling in ectopic tongue pain associated with tooth pulp inflammation

Fig. 4

Effect of LPS-RS injection into the trigeminal ganglion in rats with tooth pulp inflammation. a Time course of the experimental procedure for the group administered LPS-RS into the trigeminal ganglion immediately preceding head withdrawal threshold measurement in rats with tooth pulp exposure (Tooth pulp exposure + Immediate LPS-RS). b Time course of the experimental procedure for the groups administered vehicle or LPS-RS into the trigeminal ganglion of rats with sham or tooth pulp exposure procedures. c The head withdrawal threshold to heat or mechanical stimulation of the ipsilateral tongue following administration of vehicle or LPS-RS into the trigeminal ganglion of rats with sham or tooth pulp exposure procedures. The two-way repeated-measures ANOVA followed by Tukey–Kramer post hoc tests were used to compare head withdrawal thresholds between groups. d Fluorogold-labeled IL-1RI-IR cells in the trigeminal ganglion following administration of vehicle or LPS-RS into the trigeminal ganglion of rats with sham or tooth pulp exposure procedures. The arrowheads indicate fluorogold-labeled IL-1RI-IR cells. Scale bar, 100 μm. e The number of each IR cell type in the trigeminal ganglion of the third branch region was calculated by using the following formula: fluorogold-labeled IL-1RI-IR cells/fluorogold-labeled cells × 100%. The one-way repeated-measures ANOVA followed by Tukey–Kramer post hoc test was employed for the comparison of the percentages of positive cells between groups. Data are expressed as the mean ± SEM

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