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Table 1 Correlations between behavioural pain responses and changes in mRNA expression

From: Spinal neuronal excitability and neuroinflammation in a model of chemotherapeutic neuropathic pain: targeting the resolution pathways

Cluster Genes Correlation of ΔCT to mechanical pain threshold
   Spearman r p value
Pro-inflammatory cascades Tlr4 −0.6398 0.0210
Nlrp1a −0.5966 0.0493
Tnfrsf1a −0.6621 0.0160
Tnfrsf1b −0.6989 0.0138
Anti-inflammatory cascades Soc2 −0.6705 0.0143
Pparg −0.7541 0.0095
Central sensitisation Grin2b −0.6677 0.0149
Chemokine Cxcl6 −0.5442 0.0704
Chemokine receptors Cxcr1 −0.5671 0.0461
Cxcr5 −0.4874 0.1021
Ccr1 −0.7106 0.0170
CX3cr1 −0.6174 0.0273
Resolvin synthetic enzyme Alox5ap −0.6989 0.0199
Cyp2j4 −0.8145 0.0019
Resolvin degradation enzyme Ptgr1 −0.6981 0.0151
  1. Fold change of mRNA expression is ΔCT of each gene of the PCX group relative to ΔCT of the control group. The mechanical pain behaviour is expressed as the number of von Frey filaments changed (ΔvF) at day 28 compared to baseline. Group sizes, n = 11-13 rats