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Fig. 1 | Journal of Neuroinflammation

Fig. 1

From: Corticosteroid receptor rebalancing alleviates critical illness-related corticosteroid insufficiency after traumatic brain injury by promoting paraventricular nuclear cell survival via Akt/CREB/BDNF signaling

Fig. 1

Effects of MP and CORT treatment on plasma CORT levels, CII, incidence of CIRCI and survival rate of rats after TBI. a Plasma CORT levels in the experimental groups before and after TBI. b Quantification of CIRCI increase index before and after TBI. c Incidence of CIRCI (n = 30 per group before injury; on postinjury day 7, n = 23 from the CCI group, n = 26 from the CCI + MPL group, n = 18 from the CCI + MPH group, n = 28 from the CCI + CORT group, n = 25 from the CCI + RU486 + MP group, n = 18 from the CCI + SPIRO+CORT group). d The survival of rats in the different groups after TBI (n = 30 per group). e The survival rate of rats with and without CIRCI (n = 74 from the CIRCI group and n = 64 from the non-CIRCI group). *P < 0.05 versus the sham control group; #P < 0.05 versus the TBI control group

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Journal of Neuroinflammation

ISSN: 1742-2094