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Fig. 7 | Journal of Neuroinflammation

Fig. 7

From: Microbial BMAA elicits mitochondrial dysfunction, innate immunity activation, and Alzheimer’s disease features in cortical neurons

Fig. 7

Bacterial effectors induce AD pathological hallmarks in cortical neurons. In primary mouse cortical neurons pre-treated with 1 μM CCCP, 3 mM BMAA, and 1 μg/μl LPS for 48 h, we determined a p-Tau Thr181 protein levels by western blot. Representative immunoblot and densitometric analysis was performed by the loading of equal amounts of protein corrected with β-actin. Data represent mean ± SEM values derived from six independent determinations and data are expressed relative to untreated neurons. *p < 0.05, when compared to untreated neurons and b cytosolic Aβ oligomers protein levels by PAGE. Representative immunoblot and densitometric analysis was performed by the loading of equal amounts of protein corrected with β-actin. Data represent mean ± SEM values derived from six independent determinations and data are expressed relative to untreated neurons. The statistical significance was determined using one-way ANOVA followed by Dunnett’s test *p < 0.05, when compared to untreated neurons

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