Fig. 2

Ac2-26 reduces glial cell marker expression during pneumococcal meningitis. Gene expression was performed 28 h after pneumococcal meningitis. Glial fibrillary acidic protein (Gfap; astrocyte marker) (a and c) and integrin alpha M (Itgam; microglia marker) (b and d) mRNA expression levels were determined in the hippocampal formation and cortex of infected and non-infected WT mice with or without Ac2-26 treatment by real-time RT-PCR (all groups n = 5; two-way ANOVA followed by Bonferroni test; **p < 0.01; ***p < 0.001)