Fig. 3

Ac2-26 ameliorates pro-inflammatory responses during pneumococcal meningitis. Twenty-eight hours after subarachnoid infection with Streptococcus pneumoniae, mRNA expression of tumor necrosis factor-α (Tnf-α) (a and e), interleukin 6 (IL-6) (b and f), Ccl3 (c and g), and Cxcl10 (d and h) were determined in the hippocampal formation and cortex of infected and non-infected WT mice with or without Ac2-26 treatment by real-time RT-PCR (all groups n = 5; two-way ANOVA followed by Bonferroni test; *p < 0.05; **p < 0.01)