Fig. 4

Ac2-26 reduces density of astrocytes during pneumococcal meningitis. a Coronal brain sections were stained with antibodies against glial fibrillary acidic protein (GFAP) to identify activated astrocytes 28 h after infection with Streptococcus pneumoniae. The right column shows the dentate gyrus in higher magnification (scale bar = 100 μm). b GFAP immunoreactive cells were quantified, and the results are shown as cells per mm² area of dentate gyrus (all groups n = 5; two-way ANOVA followed by Bonferroni test; **p < 0.01 compared to infected WT mice)